Veena Kuppayyar was born in a Telugu Brahmin family in Tiruvottiyur, near Chennai. His father Sambamoorti Sastri was a famous vocalist as well as a veena player. Kuppayyar had his initial training from his father. Later he continued his musical training under Tyagaraja and learnt the art of music composition from him. Kuppayyar later moved to Chennai and sought the patronage of the local ruler Kovur Sundara Mudaliar. Kuppayyar trained a lot of disciples, who carried forward the legacy of Tyagaraja, helping to spread his krithis. Veena Kuppayar was a talented veena player. He also learnt the violin, a new instrument to Carnatic Music at that time. He composed many varnams and krithis in particular. The most famous varnam was Sami Ninne in Shankarabharanam. When he was in his height of composing, he received the title of Asthana Vidwan. His mudra was Gopaaladaasa, in honour of his personal deity.